重组SARS-CoV-2棘突蛋白(S1亚基)(Recombinant SARS-CoV-2  Spike Protein(S1 Subunit))

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell.

50ug/¥2280 1mg/¥19800
咨询电话 010-88681766

产品货号:TL-761

重组SARS-CoV-2棘突蛋白(S1亚基),GMP级

 

英文名称:Recombinant SARS-CoV-2  Spike Protein(S1 Subunit)

 

 

产品描述(Description)

 

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-Cov-2  can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

 

 

 

分子别名(Synonym)

 

2019-nCoV coronavirus spike Protein; 2019-nCoV cov spike Protein; ncov RBD Protein, 2019-nCoV; 2019-nCoV ncov s1 Protein; 2019-nCoV NCP-CoV s1 Protein;

 

 

 

纯度(Purity)

 

>90% 采用SDS-PAGE凝胶分析

 

 

 

内毒素(Endotoxin)

 

≤0.01EU/ug(凝胶法)

 

 

 

表达宿主(Expression host)

  

人HEK293细胞

 

 

 

分子量(Molecular Weight)

 

重组SARS-CoV-2 (2019-nCoV) S1蛋白包含698个氨基酸,预测的理论分子量为78.3kd

 

 

 

蛋白序列(Protein Sequence)

 

DNA序列编码重组SARS-CoV-2 (2019-nCoV) S1蛋白表达带有His标签在C末端

 

 

 

图片(Images)

 

S1蛋白电泳图同立海源生物

 

 

 

稳定性(Stability)

 

1、冻干的样本可在4℃保存24个月,溶解后的液体可于-20℃保存6-12个月,并且避免反复冻融。

2、液体样本在-20~-80℃保存12个月,融化后需要进行分装保存于-20℃保存6-12个月,避免反复冻融。

 

 

 

组成(Component)

 

  1.  含有6%甘露醇和6%海藻糖的无菌PBS(pH7.4)的冻干粉。  

2.  0.2 μM 无菌过滤的PBS,pH 7.4的液体。  

  

 

产品描述   注意:所有产品“仅用于非临床科研用途,不用于诊断、治疗、临床或其他用途”!

IOS9001、IOS13485国家质量体系双认证          国家高新技术企业认证中关村高新技术企业认证          GMP级全万级中试车间

 

GE Wave生物反应器          CHO稳定细胞株表达          无血清培养基生产

 

质检报告(COA)下载

(下载报告需要同时满足两个条件,同时输入“产品货号”和“生产批号”,满足即可搜索出产品质检报告)

如何在产品瓶上找到产品批号?

相关产品推荐:

CIK细胞扩增试剂盒套装

CIK cell culture kit

货号:AS-15 规格:2500元/套
了解详情

AMMS®NK试剂盒套装

NK cell culture kit

货号:AS-01 规格:6000元/套
了解详情

胰酶细胞消化液(含酚红)

Trypsin-EDTA Solution

货号:AS-10 规格:100mL/¥120
了解详情

AMMS® MSC试剂盒套装2.0

MSC cell culture kit 2.0

货号:AS-13 规格:2600元/套
了解详情

AMMS® MSC试剂盒套装

MSC cell culture kit

货号:AS-09 规格:2050元/套
了解详情

扫码关注微信公众号

北京同立海源生物科技有限公司

电话:010-88681766

网址:www.seafrom.com

QQ:2850881917、2850881912

地址:北京市海淀区羊坊店路18号光耀东方广场N座821室

北京同立海源生物科技有限公司版权所有   ICP备案号:京ICP备13036197号  电话:010-88681766  QQ:2850881917   2850881912