重组人Fetuin A(Recombinant Human Fetuin A Protein)

Human Fetuin A, also known as alpha 2 -Heremans-Schmid glycoprotein, is encoded by the AHSG gene.

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产品货号:TL-758

重组人 Fetuin A/AHSG(Recombinant Human  Fetuin A/AHSG),GMP级

 

产品描述(Description)

 

Human Fetuin A, also known as alpha 2 -Heremans-Schmid glycoprotein, is encoded by the AHSG gene. It is a major plasma protein and a member of the cystatin superfamily of protease inhibitors. It is expressed by hepatocytes, the principal cell source, and by monocyte/macrophages . The major form of plasma Fetuin A corresponds to a disulfide bond-linked two chains derived from the single chain . It is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Human Fetuin A has a number of functions. It is a negative acute-phase protein with normal circulating levels in adults (300-600 μg/mL), which fall significantly (30-50%) during injury and infection. It
enhances entry of cationic inhibitors into macrophages (6). It inhibits both insulin receptor autophosphorylation and undesirable calcification . It also can act as a natural antagonist against specific TGF-β and BMP signaling proteins. Recombinant Human Fetuin A is a heterodimeric protein containing a 282 amino acid A chain and a 27 amino acid B chain. The calculated molecular weight of Recombinant Human Fetuin A is 32.9 kDa. Due to glycosylation, recombinant Fetuin A migrates at an apparent molecular weight of 45–55 kDa by SDS-PAGE run under non-reducing conditions.

 

 

分子别名(Synonym)

 

Alpha-2-HS-glycoprotein、Alpha-2-Z-globulin、Ba-alpha-2-glycoprotein、Human AHS Protein、Human FETUA Protein、Human HSGA Protein

 

 

纯度(Purity)

 

≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

 

 

内毒素(Endotoxin)

 

≤0.01EU/ug(凝胶法)

 

 

 

表达宿主(Expression host) 

  

人 HEK293 细胞

 

 

 

分子量(Molecular Weight)

 

重组人 Fetuin A/AHSG 包含 381 个氨基酸,预测的理论分子量为 41kd,还原性 SDS-PAGE 的分子量为58kd

 

 

 

蛋白序列(Protein Sequence)

 

DNA 序列编码人 Fetuin A/AHSG(UniProtKB/Swiss-Prot: P02765)表达带有 His 标签在 C 末端

 

 

来源(Source)

 

Human

 

 

储存条件(Storage)

 

冻干制剂可在 4℃保存 24 个月,溶解后的液体可置于-20℃保存 6-12 个月,避免反复冻融

 

 

提纯方法(Purification Method)

 

层析纯化

 

 

性状(Character)

 

本品为白色疏松体

 

 

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IOS9001、IOS13485国家质量体系双认证          国家高新技术企业认证中关村高新技术企业认证          GMP级全万级中试车间

 

GE Wave生物反应器          CHO稳定细胞株表达          无血清培养基生产

 

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