重组人CRP蛋白(Recombinant Human CRP Protein)

Human LAG-3 Protein 首选同立海源生物,多年从事重组蛋白、抗体、细胞培养试剂盒的研发和生产,产品涉及白细胞介素、干扰素、单抗、细胞培养试剂盒、靶点蛋白等,品控严格,高活性,高纯度,高稳定性,超低内毒素,GMP高标准生产环境。

100ug/¥680
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产品货号:TL-736

重组人CRP蛋白(Recombinant Human CRP Protein),GMP级

 

产品描述(Description)

 

C-reactive protein (CRP) is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are noncovalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively. CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL6, IL1 and glucocorticoids are the major inducer of the CRP gene. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Thus, CRP participates in the clearance of necrotic and apoptotic cells. CRP rises up to 50,000-fold in acute inflammation, such as infection. It rises above normal limits within 6 hours, and peaks at 48 hours. Its half-life is constant, and therefore its level is mainly determined by the rate of production. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.

 

 

分子别名(Synonym)

 

CRP、C-reactive Protein

 

 

纯度(Purity)

 

≥95%采用SDS-PAGE凝胶和高效液相色谱分析

 

 

内毒素(Endotoxin)

 

<0.1EU/ug

 

 

表达宿主(Expression host)

  

人HEK293细胞

 

 

来源(Source)

 

Human

 

 

分子量(Molecular Weight)

 

重组人 CRP 包含 207 个氨基酸,预测理论分子量为 24.7 kd

 

 

蛋白序列(Protein Sequence)

 

DNA序列编码人CRP( NCBI Reference Sequence: NP_000558.2)表达达带有His 标签在C 末端

 

 

稳定性(Stability)

 

冻干的样本的可以在4℃保存24个月,溶解后的液体可以于-20℃保存6-12个月,并且避免反复冻融

 

 

组成(Component)

 

含有6%甘露醇的无菌PBS(PH 7.4)的冻干粉

 

 

产品描述   注意:所有产品“仅用于非临床科研用途,不用于诊断、治疗、临床或其他用途”!

IOS9001、IOS13485国家质量体系双认证          中关村高新技术企业证书          GMP级全万级中试车间

 

GE Wave生物反应器          CHO稳定细胞株表达          无血清培养基生产

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