重组人SIRP alpha/CD172a蛋白(Recombinant Human SIRP alpha/CD172a Protein)

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a)

100ug/¥2680
咨询电话 010-88681766

产品货号:TL-729

重组人SIRP alpha/CD172a蛋白(Recombinant Human SIRP alpha/CD172a Protein),GMP级

 

产品描述(Description)

 

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells。

 

 

分子别名(Synonym)

 

SHPS1、SIRPA、CD172A、BIT、MFR、MYD1、P84、PTPNS1

 

 

纯度(Purity)

 

≥95%采用SDS-PAGE凝胶和高效液相色谱分析

 

 

内毒素(Endotoxin)

 

<0.1EU/ug

 

 

表达宿主(Expression host)

 

人HEK293细胞

 

 

来源(Source)

 

Human

 

 

分子量(Molecular Weight)

 

重组人SIRP alpha蛋白 包含241个氨基酸,预测理论分子量为39kd

 

 

蛋白序列(Protein Sequence)

 

DNA序列编码人SIRP alpha(NCBI Reference Sequence:NP_542970.1)表达带有His标签在C末端

 

 

 

生物活性(Biological Activity)

 

固定人CD47(Fc标签)5µg/mL(100µl/孔)能够结合人SIRP alpha(His标签)的线性范围是10-500ng/mL

 

 

 

稳定性(Stability)

 

冻干的样本的可以在4℃保存24个月,溶解后的液体可以于-20℃保存6-12个月,并且避免反复冻融

 

 

组成(Component)

 

含有6%甘露醇的无菌PBS(PH 7.4)的冻干粉

 

 

产品描述    注意:所有产品“仅用于非临床科研用途,不用于诊断、治疗、临床或其他用途”!

IOS9001、IOS13485国家质量体系双认证          中关村高新技术企业证书          GMP级全万级中试车间

 

GE Wave生物反应器          CHO稳定细胞株表达          无血清培养基生产

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